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pentobarbital will lower the extent or effect of estradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will reduce the level or effect of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital boosts toxicity of buprenorphine, long-performing injection b